Cure for breast cancer?????

[bodeen]

Hello members,

Let me start with I lost my mom in 2006 because of cancer (she was 57) and my aunt was diagnosed with breast cancer the same year. She's going strong and winning the battle so far. Today as I was listening to a local radio station (1080 KRLD the DFW area) a gentleman from Penn State University was talking about their findings with the AAV2 virus that kills all stages of breast cancer. In the short interview he stated their research was unable to get federal or private funding. He stated their research would take years to complete without some form of funding. I pray someone opens their wallet. When I got home I did a quick search on the AAV2 virus and the link is below..

http://live.psu.edu/story/55260

Virus kills breast cancer cells in laboratory

Thursday, September 22, 2011

HERSHEY, Pa. -- A nondisease-causing virus kills human breast cancer cells in the laboratory, creating opportunities for potential new cancer therapies, according to Penn State College of Medicine researchers who tested the virus on three different breast cancer types that represent the multiple stages of breast cancer development.

Adeno-associated virus type 2 (AAV2) is a virus that regularly infects humans but causes no disease. Past studies by the same researchers show that it promotes tumor cell death in cervical cancer cells infected with human papillomavirus. Researchers used an unaltered, naturally occurring version of AAV2 on human breast cancer cells.

"Breast cancer is the most prevalent cancer in the world and is the leading cause of cancer-related death in women," said Samina Alam, research associate in microbiology and immunology. "It is also complex to treat."

Craig Meyers, professor of microbiology and immunology, said breast cancer is problematic to treat because of its multiple stages. "Because it has multiple stages, you can't treat all the women the same. Currently, treatment of breast cancer is dependent on multiple factors such as hormone-dependency, invasiveness and metastases, drug resistance and potential toxicities. Our study shows that AAV2, as a single entity, targets all different grades of breast cancer."

Cells have multiple ways of dying. If damage occurs in a healthy cell, the cell turns on production and activation of specific proteins that allow the cell to commit suicide. However, in cancer cells these death pathways often are turned off, while the proteins that allow the cell to divide and multiply are stuck in the "on" position.

One way to fight cancer is to find ways to turn on these death pathways, which is what researchers believe is happening with the AAV2 virus.

In tissue culture dishes in the laboratory, 100 percent of the cancer cells are destroyed by the virus within seven days, with the majority of the cell death proteins activated on the fifth day. In another study, a fourth breast cancer derived cell line, which is the most aggressive, required three weeks to undergo cell death.

"We can see the virus is killing the cancer cells, but how is it doing it?" Alam said. "If we can determine which viral genes are being used, we may be able to introduce those genes into a therapeutic. If we can determine which pathways the virus is triggering, we can then screen new drugs that target those pathways. Or we may simply be able to use the virus itself."

Research needs to be completed to learn how AAV2 is killing cancer cells and which of its proteins are activating the death pathways. According to Meyers, the cellular myc gene seems to be involved. While usually associated with cell proliferation, myc is a protein also known to promote cell death. The scientists have observed increased expression of myc close to the time of death of the breast cancer cells in the study. They report their results in a recent issue of Molecular Cancer.

AAV2 does not affect healthy cells. However, if AAV2 were used in humans, the potential exists that the body's immune system would fight to remove it from the body. Therefore, by learning how AAV2 targets the death pathways, researchers potentially can find ways to treat the cancer without using the actual virus.

In ongoing studies, the Penn State researchers also have shown AAV2 can kill cells derived from prostate cancer, methoselioma, squamous cell carcinoma, and melanoma. A fourth line of breast cancer cells -- representing the most aggressive form of the disease -- also was studied in a mouse breast tumor model, followed by treatment with AAV2. Preliminary results show the destruction of the tumors in the mice, and researchers will report the findings of those mouse studies soon.

Other researchers on this project are Brian S. Bowser and Mohd Israr, Department of Microbiology and Immunology; Michael J. Conway, Section of Infection Diseases, Yale School of Medicine; and Apurva Tandon, Department of Microbiology, Immunology and Pathology, Colorado State University.

The Pennsylvania Department of Health, Breast and Cervical Cancer Initiative supported this research. The researchers have filed for a U.S. patent on this work.

Radio station website - If anyone can find a podcast around 1:00pm central

http://dfw.cbslocal.com/tag/1080-krld/

God Bless

Bodeen

[ems]

Great post and it's potentially good news. The question is why is there no funding for this? Could it be because the virus cannot be synthesized in a laboratory and would therefore not reap rewards for drug manufacturers? Or is it because this will put an end to their chemical cocktails, radiotherapy and surgical interventions? I can assure you that if patients with breast cancer would become as vocal as those with AIDS, the government would print more money to fund the research. Let's hope the studies move from in vitro to in vivo soon.

[gcar]

How exciting that there may be a future cure for breast cancer. I would be happy to contribute for further research as breast cancer runs in my family. My sister had a mastectomy four years ago and, so far, is cancer-free. Her husband has been fighting bladder cancer for two years now and it is so heartbreaking to watch him in pain and depression. Cancer affects all!

[mikey]

check out Vitamin B 17 It was out

lawed in the early 60's as the cure for cancer. look a MMS and Cantron too!!

[Butifldrm]

bodeen, sorry about your mom. I know one day there will be a cure for breast cancer. Many people seek treatment outside our country for treatment because of ineffective conventional treatment or lack of FDA approval for more innovative treatment . My own family has been plagued with breat cancer. My mom had breast cancer, and survived because of early detection, she was in her early 60's (hormone therapy) the culprit. I lost my niece 2 yrs ago, she was 36, diagnosed at 31 and had chemotherapy continuous for 1 yr and then every Friday for the remainder of her life. (Chemotherapy the culprit). Moral of the story, family history, age of diagnosis and early detection. Because of the the latigenous nature of our country, the most innovative treatment will probably still be only accessible out our country. (Sad)

[bodeen]

Great post and it's potentially good news. The question is why is there no funding for this? Could it be because the virus cannot be synthesized in a laboratory and would therefore not reap rewards for drug manufacturers? Or is it because this will put an end to their chemical cocktails, radiotherapy and surgical interventions? I can assure you that if patients with breast cancer would become as vocal as those with AIDS, the government would print more money to fund the research. Let's hope the studies move from in vitro to in vivo soon.

Thank you for your post... Some things must be said!!!!

How exciting that there may be a future cure for breast cancer. I would be happy to contribute for further research as breast cancer runs in my family. My sister had a mastectomy four years ago and, so far, is cancer-free. Her husband has been fighting bladder cancer for two years now and it is so heartbreaking to watch him in pain and depression. Cancer affects all!

I'm so sorry for your family's hard times... I'm with you in pray for all family members in the above post!!!!!

bodeen, sorry about your mom. I know one day there will be a cure for breast cancer. Many people seek treatment outside our country for treatment because of ineffective conventional treatment or lack of FDA approval for more innovative treatment . My own family has been plagued with breat cancer. My mom had breast cancer, and survived because of early detection, she was in her early 60's (hormone therapy) the culprit. I lost my niece 2 yrs ago, she was 36, diagnosed at 31 and had chemotherapy continuous for 1 yr and then every Friday for the remainder of her life. (Chemotherapy the culprit). Moral of the story, family history, age of diagnosis and early detection. Because of the the latigenous nature of our country, the most innovative treatment will probably still be only accessible out our country. (Sad)

So sorry for your loss and so happy for the life you still have with you... (MOM).... A cure is out there for this mess and it would only take some MONEY!!!!!

God Bless

Bodeen

[Boiler]

Thanks for the post. So sorry for the loss of your mother. Glad to hear your aunt is doing okay. My best friend in the entire world was diagnosed with Stage IV Breast Cancer(age 32). She is kicking ass. Never underestimate the impossible.

[bodeen]

Thanks for the post. So sorry for the loss of your mother. Glad to hear your aunt is doing okay. My best friend in the entire world was diagnosed with Stage IV Breast Cancer(age 32). She is kicking ass. Never underestimate the impossible.

AMEN!!!!! Boiler your friend is LUCKY.... Boiler +1 for ya..

[LS1Hawk]

No Press, No funding... And if this cure would to see the light of day, Big Pharma would do everything they could to discredit and destroy it's creditbility. Big Pharma would never allow anything to take away it's returning customers

It's sad we live in a world where mega corporations dictate how we live ever aspect of our life.

[tankdude]

Another research area that is starting to build interest is Redox Signalling. The key to protecting, repairing, and replacing cells is a specialized set of molecules: Redox Signaling molecules. Your own body makes them, every minute of every day. There have been about 75000 articles written in medical journals over the last few years. But as we get older, our bodies get less efficient at the process. In fact, while very young children operate at nearly 100% efficiency in what scientists call “the healing response,” a 70 year-old is operating at only 10% efficiency.

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Mods, if I'm out of line on this, let me know.

Thanks