coorslite21 Posted April 4, 2020 Report Share Posted April 4, 2020 Even in the 60"s in Tokyo you would see citizens walking around with masks.....they had colds.....or anything else.....and it was considered to be the polite thing to do....wear a mask to prevent others from catching what you had... Guidance suggesting not wearing masks is/was idiotic. Now let's talk Hydroxychloroquine .....this was approved by the USDA in 1955 for malaria .....off label use for anything should be looked at as safe.....do your own research.....are they lying again to us about this..... The HCQ story begins in 1638 when the wife of the Viceroy of Peru, Countess Cinchona, acquired malaria while living in the New World. Rather than getting the “approved” therapy, blood-letting, she was treated by an Incan herbalist with the bark of a tree (eventually, named for the countess-Cinchona Tree). Her response was dramatic; when the Viceroy returned to Spain, he brought with him large supplies of the powder for general use, which at the time was controlled by the Church and was thus called “Jesuit’s Powder”. It took nearly two centuries for the active substance, Quinine, to be isolated from the bark (and was eventually to make a name for itself as a tonic to be added to gin). Over the next century, quinine would become a common component in folk medicines and patent remedies for the treatment of malaria in the southern states of America, as well as for generic malaise. By the 1940s, quinine, or rather its derivative chloroquine, was recognized for its anti-malarial properties and found use among troops fighting in the Pacific during WW-II. However, it was noted that this compound had significant toxicities. In 1945, a modification of this compound via hydroxylation led to the development of HCQ, which was found to be less toxic and remains in use, without change, to this day. Over time, physicians began to experiment with the medication and, in the early 1950s, began to use it for the treatment of SLE. After the success in that disease (at least success relative to the other available agents which were basically none), it was tried in another arthropathy, RA. However, in the quest to get better responses, physicians would “push” the dose and, not surprisingly, toxicities, most notable retinal toxicity, began to present itself as a limiting feature of the medication. Not deterred, physicians adjusted the dose and began to consider using it in combination therapy, which became popular in the 1980s and has culminated in the recent studies showing the notable efficacy of triple therapy when HCQ was combined with MTX and sulfasalazine. Hydroxychloroquine was approved for medical use in the United States in 1955.[2] It is on the World Health Organization's List of Essential Medicines, the safest and most effective medicines needed in a health system.[6] In 2017, it was the 128th-most-prescribed medication in the United States, with more than five million prescriptions.[7] CL 2 1 Quote Link to comment Share on other sites More sharing options...
coorslite21 Posted April 4, 2020 Author Report Share Posted April 4, 2020 Masks can be as simple as multi layers of scarfing.....here's one more idea......CL https://m.facebook.com/crisisresponse/213082643232813/post/214317163109361/ 2 1 Quote Link to comment Share on other sites More sharing options...
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