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Natural Migraine help


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Not to sound like a broken record (but in many ways, I am...) new research is showing that migraines may have a tie in with oxidative stress - in other words, a redox pathology. (Yep, there I go again with that redox stuff.)

http://www.ncbi.nlm.nih.gov/pubmed/21222375

"CONCLUSIONS:In this study, we demonstrated that the levels of total antioxidants were decreased and the levels of total oxidants and the oxidative stress index were increased in patients with Migraine with out Aura (MWoA). These findings may be an evidence of exposure to potent oxidative stress in MWoA patients"

http://www.ncbi.nlm.nih.gov/pubmed/21518147

CONCLUSIONS: We show here that increased oxidative stress is associated with migraine and contributes to migraine-related metabolic risk like nitrosative stress, an atherogenic lipid profile and hyperinsulinemia. Our data suggest that oxidative stress may represent a key event in the pathophysiology of migraine and a suitable therapeutic target."
 
One of the things I found that might be of help is oral niacin...the quick release type. Stay away from the sustained release.

"With respect to the oral administration of niacin, very few patients reported side effects. Even though niacin was well tolerated orally, we previously reported in a randomized placebo-controlled trial examining the safety of immediate-release or crystalline niacin, that it can be associated with intolerable side effects [36]. The most common side effects found using 500 mg of immediate-release niacin were unpleasant warmth or flushing, pruritis, chills, tingling, nausea, and vomiting. Approximately 75% of the subjects who were given niacin found it tolerable or difficult to tolerate, but did not indicate that they would never take niacin again. Some 18.2% of the niacin subjects indicated that they found niacin to be intolerable and would never take it again [36]. By contrast, very few of the patients from the summarized articles discontinued treatment due to the side effects of oral niacin.

http://dinarvets.com/forums/index.php?/topic/205064-natural-migraine-help/

The side effects of greater concern from oral niacin have to do with sustained- or slow-release preparations. These preparations are better in terms of compliance since patients experience less cutaneous flushing with them. However, the use of these preparations have been associated with reversible hepatic toxicity in doses equal to or greater than 1500 mg per day with an acute onset of clinical symptoms of hepatitis in a relatively short period of time (2 days to 7 weeks) [37]. Other reports have demonstrated clinical symptoms of hepatitis when much larger doses of sustained-release niacin (greater than or equal to 3 grams per day) were used for months to years [38-42]. Sustained-release preparations have a higher incidence of hepatic toxicity in doses comparable to the immediate-release preparations [43], but these important differences are not typically mentioned in reviews of niacin's lipid lowering properties. "
 

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